cas 27192-21-8|| where to buy 5-Bromo-4-chloro-6-cyclopropylpyrimidine

Product Name:5-Bromo-4-chloro-6-cyclopropylpyrimidine

IUPAC Name:5-bromo-4-chloro-6-cyclopropylpyrimidine

: CAS：27192-21-8; Molecular Formula：C7H6BrClN2; Purity：95%+

: Catalog Number：CM1051304; Molecular Weight：233.49

Packing Unit	Available Stock	Price($)
CM1051304-100mg	in stock	Ōǟ
CM1051304-250mg	in stock	ǟħǟ

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Product Details

: CAS NO:27192-21-8; Molecular Formula:C7H6BrClN2; Melting Point:-; Smiles Code:ClC1=C(Br)C(=NC=N1)C1CC1; Density:

: Catalog Number:CM1051304; Molecular Weight:233.49; Boiling Point:; MDL No:MFCD11047047; Storage:

Category Infos

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

Column Infos

: TNG348; Dose escalation is ongoing in the TNG348, a novel inhibitor of USP1 (ubiquitin-specific protease 1), phase 1/2 clinical trial evaluating the safety, pharmacokinetics, pharmacodynamics and efficacy of TNG348 as a single agent and in combination with olaparib, a PARP inhibitor, in patients with BRCA1/2 mutant and other HRD+ (homologous recombination deficient) cancers. The first patient dosed was announced in January 2024.Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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