Product Name:3-aminopiperidine-2,6-dione

IUPAC Name:3-aminopiperidine-2,6-dione

CAS:2353-44-8
Molecular Formula:C5H8N2O2
Purity:95%
Catalog Number:CM132080
Molecular Weight:128.13

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Product Details

CAS NO:2353-44-8
Molecular Formula:C5H8N2O2
Melting Point:-
Smiles Code:NC1CCC(=O)NC1=O
Density:
Catalog Number:CM132080
Molecular Weight:128.13
Boiling Point:334.5°C at 760 mmHg
MDL No:MFCD11506223
Storage:Keep in dark place, store at 2-8°C.

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos

NX-2127
Existing BTK inhibitors directly bind to the active site of BTK and face challenges such as acquired resistance or incomplete responses over time. PROTAC-induced BTK degradation works as a novel alternative therapy for drug-resistant cancers. The latest journal Science publishes the identification of BTK mutations that are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Nurix Therapeutics’ TPD compound NX-2127 is a first-in-class, dual-function small-molecule protein degrader. It drives targeted BTK and transcription factor IKAROS (IKZF1/3) degradation through ubiquitination and proteasomal degradation, adding combined benefit. NX-2127 is under development of phase I clinical trials that shows promising results and a manageable safety profile for the treatment of relapsed/ refractory B-cell malignancies.