Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.
Pyrrolizine derivatives are a class of heterocyclic compounds that can be used as scaffolds for anticancer drugs. The unique antitumor properties of mitomycin C have prompted chemists to develop different pyrrolizine systems and evaluate their potential antitumor activity against a variety of cancers.
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