Product Name:(R)-1,1,1-Trifluoropropan-2-amine hydrochloride

IUPAC Name:(2R)-1,1,1-trifluoropropan-2-amine hydrochloride

CAS:177469-12-4
Molecular Formula:C3H7ClF3N
Purity:95%+
Catalog Number:CM250388
Molecular Weight:149.54

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CM250388-25g in stock ƿIJƈ

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Product Details

CAS NO:177469-12-4
Molecular Formula:C3H7ClF3N
Melting Point:-
Smiles Code:C[C@@H](N)C(F)(F)F.[H]Cl
Density:
Catalog Number:CM250388
Molecular Weight:149.54
Boiling Point:116°C at 760 mmHg
MDL No:MFCD07779095
Storage:Store at room temperature

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Fluorinated Compounds
Fluorine is the most electronegative element in the periodic table, and the fluorine atom has a small atomic radius, so fluorine-containing organic compounds have many wonderful properties. For example, the introduction of fluorine atoms or fluorine-containing groups into drug molecules can improve the permeability to cell membranes, metabolic stability and bioavailability; in addition, the introduction of fluorine atoms will improve the lipid solubility of the compound and promote its absorption in the body. The speed of delivery changes the physiological effect. In the field of medicinal chemistry, the introduction of fluorine atoms into organic molecules is an important direction for the development of new anticancer drugs, antitumor drugs, antiviral agents, anti-inflammatory drugs, and central nervous system drugs.

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Fluorinated compounds
Fluorinated compounds refers to organic or inorganic compounds containing fluorine.
Vorasidenib
Servier presented the latest clinical data on the IDH1/2 inhibitor vorasidenib (AG-881) in the treatment of IDH-mutated diffuse glioma at the 28th Annual Meeting of the Society of Neuro-Oncology (SNO). Blinded independent radiology committee evaluation showed that vorasidenib significantly reduced tumor growth and not only preserved the patient's quality of life, but also stabilized neurocognitive function and controlled epilepsy. Based on these results, the company plans to submit a new drug application for vorasidenib to the U.S. FDA by the end of 2023 for the treatment of IDH-mutated diffuse glioma. Vorasidenib is an oral, brain-penetrating and selective dual inhibitor under development that can inhibit mutated IDH1/2 proteins and is a potential "first-in-class" drug. It has received breakthrough therapy designation from the FDA.
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