Dioxolane is a heterocyclic acetal with the formula (CH2)2O2CH2. It is related to tetrahydrofuran by exchanging an oxygen for the CH2 group. The isomer 1,2-dioxolane (in which the two oxygen centers are adjacent) is a peroxide. 1,3-Dioxolane is used as solvent and comonomer in polyacetal. The dioxolane-type and their hydrogenolysis can provide very valuable partially protected building blocks either for oligosaccharide syntheses or sugar transformations.
When the ends of the chains are joined together into a ring, cyclic compounds result; such substances often are referred to as carbocyclic or alicyclic compounds. Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound.
The S1P1 receptor, a protein that plays a pivotal role in regulating immune response, interacts with S1P, a plasma lipid mediator. Remarkably, S1P regulates an array of physiological phenomena such as angiogenesis, inflammation, immunity, cell motility, and neurotransmitter release.
Enter Cenerimod, a novel, potent, and selective S1P1 receptor modulator featuring unique signaling properties, while notably negating broncho‐ and vasoconstrictor effects. Hence, Cenerimod stands as a promising candidate in the quest for improved S1P1 receptor modulators.