Naturally occurring steroids are estrogen, cortisol, progesterone, and testosterone. Pharmacologically, they are used in several ways: alter steroid metabolism via statins to help lower cholesterol; as corticosteroids to help control inflammation, asthma, and lupus; and other forms to help hormone deficiency, such as delayed puberty, as well as diseases that result in loss of lean muscle mass, such as cancer and AIDS.
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ZURZUVAE was approved by the FDA in August 2023 as the first-and-only oral treatment specifically indicated for adults with postpartum depression (PPD). Zuranolone is a next-generation positive allosteric modulator (PAM) of GABAA receptors being evaluated as a treatment for various affective disorders.