Product Name:6-(Cyclopropyl)pyrazine-2-boronic acid pinacol ester

IUPAC Name:3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (6-cyclopropylpyrazin-2-yl)boronate

CAS:1412905-41-9
Molecular Formula:C13H21BN2O3
Purity:95%+
Catalog Number:CM325331
Molecular Weight:264.13

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Product Details

CAS NO:1412905-41-9
Molecular Formula:C13H21BN2O3
Melting Point:-
Smiles Code:OB(C1=NC(C2CC2)=CN=C1)OC(C)(C(C)(C)O)C
Density:
Catalog Number:CM325331
Molecular Weight:264.13
Boiling Point:
MDL No:
Storage:

Category Infos

Pyrazines
Pyrazine is a heterocyclic aromatic organic compound with chemical formula C4H4N2. The marketed pyrazine drugs are mainly distributed in the field of anti-tumor and anti-infection. In recent years, there have been many new drugs in various fields, and there are some new target drugs worthy of attention.
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Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Cyclopropanes
Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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