Borates are classified as critical materials, they are the main source of boron and have a variety of industrial applications. Organic trifluoroborate is stable to heat, air and humidity, and is a very convenient crystalline boric acid compound. Since it has a tetra-coordinated boronic acid structure after the substitution of fluorine, it does not exhibit Lewis acidity and is stable to oxidation conditions. In addition, it can be regarded as the protector of boronic acid and boronic acid ester, which can be converted into each other. The compound can generally exist stably in organic solvents, but will decompose in protic solvents to liberate trivalent boron, so it can be directly used as a substrate for Suzuki coupling. The difference between trifluoroborate and boric acid is that it must exist in a monomeric form, so the equivalent weight can be closely controlled.
The molecular structure of cyclobutane has four carbon atoms, and its four carbon atoms are not in the same plane, which is the folded conformation of cyclobutane. Cyclobutane itself is not of commercial or biological interest, but more complex derivatives are important in biology and biotechnology. Currently, nine FDA-approved drugs contain the cyclobutane structure. From the perspective of therapeutic areas, cyclobutyl drugs are mainly distributed in popular areas such as tumors, neurological diseases, infectious diseases, endocrine and metabolic diseases.