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Maralixibat

Mirum announced that the FDA has approved LIVMARLI® (maralixibat) oral solution , ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic pruritus in patients five years of age and older with progressive familial intrahepatic cholestasis (PFIC). Mirum has also submitted an additional supplemental new drug application (sNDA) to introduce a higher concentration formulation of LIVMARLI, used during the MARCH study, to enable label expansion for younger patients with PFIC, later this year.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

(2-Chloro-5-nitrophenyl)(4-methoxyphenyl)methanone
(2-Chloro-5-nitrophenyl)(4-methoxyphenyl)methanone
CM306390
70132-87-5
1-chloro-2-[(4-methoxyphenyl)methyl]-4-nitrobenzene
1-chloro-2-[(4-methoxyphenyl)methyl]-4-nitrobenzene
CM1046158
197378-07-7
2-butyl-2-({2-[(4-methoxyphenyl)methyl]-4-nitrobenzenesulfonyl}methyl)hexanal
2-butyl-2-({2-[(4-methoxyphenyl)methyl]-4-nitrobenzenesulfonyl}methyl)hexanal
CM1046161
197378-31-7
(4R,5R)-3,3-dibutyl-7-(dimethylamino)-4-hydroxy-5-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1λ⁶-benzothiepine-1,1-dione
(4R,5R)-3,3-dibutyl-7-(dimethylamino)-4-hydroxy-5-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1λ⁶-benzothiepine-1,1-dione
CM1046157
197373-42-5
(4R,5R)-3,3-dibutyl-7-(dimethylamino)-4-hydroxy-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1λ⁶-benzothiepine-1,1-dione
(4R,5R)-3,3-dibutyl-7-(dimethylamino)-4-hydroxy-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1λ⁶-benzothiepine-1,1-dione
CM1046176
228113-65-3