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Imidazopyrazines

In addition to the nitrogen-based heterocycles presented so far, a number of others nitrogen-based scaffolds have also been reported as promising agents for GBM treatment, including pyrazolo-triazole, imidazotetrazine, piperidine, purine, imidazopyrazine, pyrazole, triazole among others.

3-bromo-6-iodoimidazo[1,2-a]pyrazine

6-bromoimidazo[1,2-a]pyrazine-2-carboxylic acid

ethyl imidazo[1,2-a]pyrazine-3-carboxylate

5,8-dibromoimidazo[1,2-a]pyrazine

6-bromoimidazo[1,2-a]pyrazine-3-carbaldehyde

tert-butyl 3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

3-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

4-(imidazo[1,2-a]pyrazin-2-yl)-1,2,5-oxadiazol-3-amine

Imidazo[1,2-a]pyrazine-3-carbaldehyde

(S)-6-(benzo[d][1,3]dioxol-5-yl)-1-(1-phenylethyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one

4-(6-bromoimidazo[1,2-a]pyrazin-8-yl)morpholine

imidazo[1,2-a]pyrazin-3-ylmethanol

6-bromo-N-methylimidazo[1,2-a]pyrazin-8-amine

6-Bromoimidazo[1,2-a]pyrazine-8-carboxylic acid

3-iodo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

5-chloroimidazo[1,2-a]pyrazine-2-carboxylic acid

tert-Butyl 3-iodo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate

7-Benzyl-3-bromo-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazine

8-methyl-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

ethyl 7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

7-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carbaldehyde

8-chloro-6-phenylimidazo[1,2-a]pyrazine

5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine dihydrochloride

6-chloro-8-(piperazin-1-yl)imidazo[1,2-a]pyrazine