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Furazans

Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. Oxadiazoles are a class of five-membered heterocycles containing one oxygen and two nitrogen atoms with special biological activity and thermodynamic properties. 1,2,4- and 1,3,4-oxadiazoles are widely used in the development of bioactive molecules, but 1,2,5-oxadiazoles (furazans) are used relatively sparingly. Compared with 1,2,4- and 1,3,4-isomers, 1,2,5-oxadiazole has unique physicochemical properties and electronic effects. The furazan ring has a strong inductive effect, comparable to that of trifluoromethyl or tetrazolyl. The unique properties of furoxan can confer specific pharmacological activities to drug-like molecules.

4-nitro-1,2,5-oxadiazol-3-amine
4-nitro-1,2,5-oxadiazol-3-amine
CM105286
66328-69-6
N-(4-amino-1,2,5-oxadiazol-3-yl)acetamide
N-(4-amino-1,2,5-oxadiazol-3-yl)acetamide
CM105287
140706-47-4
(4-amino-1,2,5-oxadiazol-3-yl)methanol
(4-amino-1,2,5-oxadiazol-3-yl)methanol
CM105288
1092310-34-3
(4-methyl-1,2,5-oxadiazol-3-yl)methanamine
(4-methyl-1,2,5-oxadiazol-3-yl)methanamine
CM105289
321392-83-0
ethyl 4-methyl-1,2,5-oxadiazole-3-carboxylate
ethyl 4-methyl-1,2,5-oxadiazole-3-carboxylate
CM105290
32551-32-9
(4-Amino-1,2,5-oxadiazol-3-yl)(piperidin-1-yl)methanone
(4-Amino-1,2,5-oxadiazol-3-yl)(piperidin-1-yl)methanone
CM110009
329922-46-5
(E)-4-amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide
(E)-4-amino-N
CM110285
354543-09-2
2,1,3-benzoxadiazol-4-amine
2,1,3-benzoxadiazol-4-amine
CM112826
767-63-5
3-Acetyl-4-amino-1,2,5-oxadiazole
3-Acetyl-4-amino-1,2,5-oxadiazole
CM119193
17647-71-1
3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one
3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one
CM119269
914471-43-5
3-(4-Bromophenyl)-1,2,5-oxadiazole
3-(4-Bromophenyl)-1,2,5-oxadiazole
CM120028
71420-03-6
4-(3-Bromo-4-fluorophenyl)-3-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5(4H)-one
4-(3-Bromo-4-fluorophenyl)-3-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5(4H)-one
CM120030
2019140-71-5
(4-methyl-1,2,5-oxadiazol-3-yl)methanamine hydrochloride
(4-methyl-1,2,5-oxadiazol-3-yl)methanamine hydrochloride
CM130692
1159825-48-5
4-(imidazo[1,2-a]pyrazin-2-yl)-1,2,5-oxadiazol-3-amine
4-(imidazo[1,2-a]pyrazin-2-yl)-1,2,5-oxadiazol-3-amine
CM133682
1031927-02-2
4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine
4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine
CM150909
607368-87-6
4-{7-Bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine
4-{7-Bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine
CM150910
607370-99-0
2-(4-Amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol
2-(4-Amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol
CM150945
842149-46-6
3-(4-((2-Aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide
3-(4-((2-Aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide
CM182739
1204669-57-7
4-Amino-3-furazanecarboxamidoxime
4-Amino-3-furazanecarboxamidoxime
CM196173
13490-32-9
Methyl-(4-methyl-furazan-3-ylmethyl)-amine
Methyl-(4-methyl-furazan-3-ylmethyl)-amine
CM196310
588730-16-9
Furazan-3,4-diamine
Furazan-3,4-diamine
CM196494
17220-38-1
1-((4-Methyl-1,2,5-oxadiazol-3-yl)methyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-((4-Methyl-1,2,5-oxadiazol-3-yl)methyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CM261483
1351382-95-0
4-Methyl-1,2,5-oxadiazole-3-carbaldehyde
4-Methyl-1,2,5-oxadiazole-3-carbaldehyde
CM274878
90507-35-0
4-Amino-N-methyl-1,2,5-oxadiazole-3-carboxamide
4-Amino-N-methyl-1,2,5-oxadiazole-3-carboxamide
CM281244
30720-84-4